microdose flare-up gonadotropin-releasing hormone (gnrh) agonist versus gnrh antagonist protocols in poor ovarian responders undergoing intracytoplasmic sperm injection
نویسندگان
چکیده
background: microdose flare-up gnrh agonist and gnrh antagonist have become more popular in the management of poor ovarian responders (por) in recent years; however, the optimal protocol for por patients undergoing in vitro fertilization has still been a challenge. methods: in this observational study design, two hundred forty four poor ovarian responders were retrospectively evaluated for their response to gnrh agonist protocol (group-1, n=135) or gnrh antagonist protocol (group-2, n=109). clinical pregnancy rate was the primary end point and was compared between the groups. student t-test, mann whitney u test and x2-test were used to compare the groups. the p<0.05 was considered to show a statistically significant result. results: the mean total gonadotropin doses were 3814±891 iu in group 1 and 3539±877 iu in group 2 (p=0.02). the number of metaphase-ii oocytes (3.6±2.4 vs. 2.8±1.9, p=0.005) and implantation rates (27.8% vs. 18.8%, p=0.04) in group 1 and group 2, respectively were significantly different. the fertilization rate in group 1 and group 2 was 73% vs. 68%, respectively (p=0.5) and clinical pregnancy rate was 19.8% vs. 14.4%, respectively (p=0.13). conclusion: the gnrh agonist microdose flare-up protocol has favorable outcomes with respect to the number of oocytes retrieved and implantation rate; nevertheless, the clinical pregnancy rate was found to be similar in comparison to gnrh antagonist protocol in poor ovarian responders. gnrh antagonist protocol appears to be promising with significantly lower gonadotropin requirement and lower treatment cost in poor ovarian responders.
منابع مشابه
Microdose Flare-up Gonadotropin-releasing Hormone (GnRH) Agonist Versus GnRH Antagonist Protocols in Poor Ovarian Responders Undergoing Intracytoplasmic Sperm Injection
BACKGROUND Microdose flare-up GnRH agonist and GnRH antagonist have become more popular in the management of poor ovarian responders (POR) in recent years; however, the optimal protocol for POR patients undergoing in vitro fertilization has still been a challenge. METHODS In this observational study design, two hundred forty four poor ovarian responders were retrospectively evaluated for thei...
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Letrozole+ GnRH antagonist stimulation protocol in poor ovarian responders undergoing intracytoplasmic sperm injection cycles: An RCT
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متن کاملComparisons of GnRH antagonist versus GnRH agonist protocol in poor ovarian responders undergoing IVF.
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متن کاملA Flexible Multidose GnRH Antagonist versus a Microdose Flare-Up GnRH Agonist Combined with a Flexible Multidose GnRH Antagonist Protocol in Poor Responders to IVF
OBJECTIVE To compare the effectiveness of a flexible multidose gonadotropin-releasing hormone (GnRH) antagonist against the effectiveness of a microdose flare-up GnRH agonist combined with a flexible multidose GnRH antagonist protocol in poor responders to in vitro fertilization (IVF). STUDY DESIGN A retrospective study in Akdeniz University, Faculty of Medicine, Department of Obstetrics and ...
متن کاملMicrodose GnRH Agonist Flare-Up versus Ultrashort GnRH Agonist Combined with Fixed GnRH Antagonist in Poor Responders of Assisted Reproductive Techniques Cycles
BACKGROUND This study compares the microdose flare-up protocol to the ultrashort gonadotropinreleasing hormone (GnRH) agonist flare combined with the fixed multidose GnRH antagonist protocol in poor responders undergoing ovarian stimulation. MATERIALS AND METHODS In this randomized clinical trial, 120 women who were candidates for assisted reproductive techniques (ART) and had histories of on...
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عنوان ژورنال:
journal of reproduction and infertilityجلد ۱۷، شماره ۳، صفحات ۱۶۳-۱۶۹
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